Researchers from Finland and Norway developed a new suite of methods for the screening of antivirulence activity of unknown compounds of bacterial origin. The compounds tested had been derived from actinobacteria living inside invertebrates in the Arctic Sea. They found two interesting compounds with strong antivirulence or antibacterial effects against enteropathogenic E. coli. These results demonstrate the potential of prospecting novel habitats for promising new antibacterial drugs, to solve the current global antibiotics crisis.